Cancer : Regulatory Proteins
The point is clearly and helpfully made
that Ross Sarcoma Virus has its strongest impact on young chickens.
Also the leucosis viruses are only likely to produce leukemia,
if they infect young chickens.
In other articles the point is made that a sequence of events is required
before the rapidly dividing cells of a highly malignant tumour can be established.
One of those events is a cell needs to be in a healing (cell reproducing) phase.
This means the proteins which latch onto the motif sequences of DNA
which regulate transcription of DNA at sites on the DNA
which may be a thousand or more base pairs away
have to be in position because of the wound!
The wound creates the condition which either forms
or releases these regulating proteins.
If their wound coincides with a viral infection,
the virus will have the possibility of having its genetics transcribed.
Remember, however, that the characteristic of cancer is rapidly reproducing cells
which are undifferentiated.
The regulatory proteins which control transcription are helical
with leucine zippers* (see Scientific American article).
If these regulatory proteins are able to situate and release
from the motif sites on the DNA easily, then differentiated growth is possible.
If, however, these regulatory proteins are unable to get loose
from the site of the motif, because, for instance,
the pitch of the helix has been affected in the regulatory protein,
then the reproduction or transcription would be undifferentiated, rapid
and, in fact, cancerous.
If you study the work of Jim Sheridan, he points out exactly when and how
just such a distortion of such regulatory proteins occurs.
copyright 2011, 2013, ECOhealth / Eve Revere
