Greetings To All,

SCMN Holiday Giving

Toy and Food Drive Donation

Benefiting children with Red Blood Cell Disorders

Sickle-cell disease (SCD), or sickle-cell anaemia (or anemia, SCA) or drepanocytosis, is an autosomal recessive genetic blood disorder with overdominance, characterized by red blood cells that assume an abnormal, rigid, sickle shape. Sickling decreases the cells’ flexibility and results in a risk of various complications. The sickling occurs because of a mutation in the haemoglobin gene. Life expectancy is shortened, with studies reporting an average life expectancy of 42 years in males and 48 years in females.[1]

Sickle-cell disease, usually presenting in childhood, occurs more commonly in people (or their descendants) from parts of tropical and sub-tropical regions where malaria is or was common. One-third of all indigenous inhabitants of Sub-Saharan Africa carry the gene,[2] because in areas where malaria is common, there is a fitness benefit in carrying only a single sickle-cell gene (sickle cell trait). Those with only one of the two alleles of the sickle-cell disease, while not totally resistant, are more tolerant to the infection and thus show less severe symptoms when infected.[3]

The prevalence of the disease in the United States is approximately 1 in 5,000, mostly affecting Americans of Sub-Saharan African descent, according to the National Institutes of Health.[4] In the United States, about 1 out of 500 African-American children born will have sickle-cell anaemia.[5]

Sickle-cell anaemia is the name of a specific form of sickle-cell disease in which there is homozygosity for the mutation that causes HbS. Sickle-cell anaemia is also referred to as “HbSS”, “SS disease”, “haemoglobin S” or permutations thereof. In heterozygous people, who have only one sickle gene and one normal adult haemoglobin gene, it is referred to as “HbAS” or “sickle cell trait”. Other, rarer forms of sickle-cell disease include sickle-haemoglobin C disease (HbSC), sickle beta-plus-thalassaemia (HbS/β+) and sickle beta-zero-thalassaemia (HbS/β0). These other forms of sickle-cell disease are compound heterozygous states in which the person has only one copy of the mutation that causes HbS and one copy of another abnormal haemoglobin allele.

The term disease is applied, because the inherited abnormality causes a pathological condition that can lead to death and severe complications. Not all inherited variants of haemoglobin are detrimental, a concept known as genetic polymorphism. Thanks to Wikipedia.

As we prepare our homes for the holidays, some kids hope for gifts that are wrapped with pretty paper and ribbons, instead many children are asking for Health and Strength to battle life, threatening disorders. Help make a child`s holiday wish come true. This holiday Season, please donate generously to make a difference in the lives, of children living with red blood cell disorder.

Please support our holiday giving.

Toys and food hampers will be distributed on December 19/11

Volunteers needed! student great opportunity to give

back to your community and earn your high school hours.

HAPPY HOLIDAYS! “Joy warms the heart“

For more information contact 647 920 2469 www.sicklecell.ca

You can make a difference!!!

Thanks for your support.

Naomi Jules

A community Outreach worker, Mentor, Counselor, Social Activist,
philanthropist advocating for the rights of people

Email: [email protected]

Contact Phone: 647-920-2469
“Knowledge is Power “

Free Programs and Services for individuals and their family members.
Awareness, Advocacy, Counseling, Education, Mentorship, Social Support, Scholarships, Tutoring & Grants

TJF- The Jules Foundation Scholarship Grants Application

EXCELLENCE, INTEGRITY, ACCOUNTABILITY

“Stay Focus and Be Blessed”

Naomi Jules

A community Outreach worker,Mentor,Counselor,Social Activist,
philanthropist advocating for the rights of people

Email: [email protected]

Contact Phone: 647-920-2469
“Knowledge is power “

Free Programs and Services for individuals and their family members.
Awareness, Advocacy, Counseling, Education, Mentorship, Social Support, Scholarships, Tutoring & Grants

TJF- The Jules Foundation Scholarship Grants Application

EXCELLENCE, INTEGRITY, ACCOUNTABILITY

“Stay Focus and Be Blessed”